Synthesis and self-assembly of supramolecular polymers and materials

Cryo-TEM image of supramolecular polymers based on bissquaramide bolaamphiphiles
Cryo-TEM image of supramolecular polymers based on bissquaramide bolaamphiphiles

Our group designs, synthesizes and aims to understand the self-assembly of new supramolecular synthons to prepare robust and responsive non-covalent biomaterials. We are further interested in the effect of functional monomers on the self-assembly processes of these materials and their resultant properties. Through a better understanding of the formation of these complex hierarchical materials, we seek to gain control over their structural and functional properties to exploit them for use in the therapeutic domain.

Disease-responsive supramolecular materials

Specific biological processes in healthy and pathological tissue states can be linked to the overexpression of certain biological markers, such as proteins or nucleic acids, and/or the increased production of reactive oxygen species or gases. We use the current knowledge of these biological processes to rationally design and synthesize supramolecular polymer materials that can respond to these microenvironments, enabling low-cost disease diagnostics and deployment of therapeutic payloads.

Cell-instructive supramolecular biomaterials

Cell fate and function is orchestrated by numerous and simultaneous biochemical and biophysical cues that originate from their natural microenvironment. We design and synthesize biomaterials endowed with specific, reversible and modular properties stemming from their non-covalent character, to recapitulate the structural and functional complexity found in natural materials from the nano- to the macroscopic scales for applications in the areas of tissue engineering and regenerative medicine.